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بحث جزائري معترف به أعطى نتائج ايجابية لبنبتة النوخة ..لقاح فيروس كورونا
#بحثجزائريمعترفبهأعطىنتائجبنبتة_النوخة
تمكن باحثون من جامعة تلمسان من التوصل عبر تقنية الإرساء الجزيئي إلى نتائج مباشرة فيما يخص وباء كورونا المستجد.
تشير دراستهم إلى مركبات من نبتة طبية تسمى بالعامية النوخة Ammoides verticillata، تعمل على حجب مستقبلات ACE2 التي يتعرف عليها الفيروس وتمكّنه من الدخول إلى الخلية وبالتالي التكاثر.
دراسة واعدة، تحية للباحثين (ايمان عبدلي، فيصل حساني، صهيب بكال بريكسي، سعيد غالم) على نشر البحث.
رابط المقال المنشور:
For More Scientific News, Facts & Images FOLLOW:
Algerian Biochemistry Research #BiochemistryResearch
——————
"In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from Western Algeria"
Imane Abdelli, Faiçal Hassani, Sohayb Bekkel Brikci & Said Ghalem
Abstract:
The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and γ-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.) Briq. which is located in the occidental Algeria areas. This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor β-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor. In silico (ADME), drug-likeness, PASS & P450 site of metabolism prediction, pharmacophore Mapper showed that the compound Isothymol has given a good tests results compared to the β-D-mannose co-crystallized inhibitor, to Captopril and Chloroquine drugs. Also the other natural compounds gave good results. The Molecular Dynamics Simulation study showed good result for the Isotymol- ACE2 docked complex. This study revealed for the first time that Isothymol is a functional inhibitor of angiotensin converting enzyme 2 activity and the components of essential oils Ammoides verticillata can be used as potential inhibitors to the ACE2 receptor of SARS-CoV-2.
تمكن باحثون من جامعة تلمسان من التوصل عبر تقنية الإرساء الجزيئي إلى نتائج مباشرة فيما يخص وباء كورونا المستجد.
تشير دراستهم إلى مركبات من نبتة طبية تسمى بالعامية النوخة Ammoides verticillata، تعمل على حجب مستقبلات ACE2 التي يتعرف عليها الفيروس وتمكّنه من الدخول إلى الخلية وبالتالي التكاثر.
دراسة واعدة، تحية للباحثين (ايمان عبدلي، فيصل حساني، صهيب بكال بريكسي، سعيد غالم) على نشر البحث.
رابط المقال المنشور:
For More Scientific News, Facts & Images FOLLOW:Algerian Biochemistry Research #BiochemistryResearch
——————
"In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from Western Algeria"
Imane Abdelli, Faiçal Hassani, Sohayb Bekkel Brikci & Said Ghalem
Abstract:
The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and γ-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.) Briq. which is located in the occidental Algeria areas. This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor β-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor. In silico (ADME), drug-likeness, PASS & P450 site of metabolism prediction, pharmacophore Mapper showed that the compound Isothymol has given a good tests results compared to the β-D-mannose co-crystallized inhibitor, to Captopril and Chloroquine drugs. Also the other natural compounds gave good results. The Molecular Dynamics Simulation study showed good result for the Isotymol- ACE2 docked complex. This study revealed for the first time that Isothymol is a functional inhibitor of angiotensin converting enzyme 2 activity and the components of essential oils Ammoides verticillata can be used as potential inhibitors to the ACE2 receptor of SARS-CoV-2.
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